Low carb diet may prevent, reverse age-related effects in brain: Study

By: PTI | Washington |

Published: March 7, 2020 3:50:07 pm

low carb, low carb diet, low carb diet indian express Do you follow a low-carb diet? (Photo: Getty Images/Thinkstock)

Minimising the consumption of carbohydrates may prevent and reverse age-related effects within the brain, according to a study.

The research, published in the journal PNAS, reveals that neurobiological changes associated with ageing can be seen at a much younger age than would be expected, in the late 40s.

To better understand how diet influences brain ageing, the researchers from Stony Brook University in the US focused on the presymptomatic period during which prevention may be most effective.

They showed, using large-scale life span neuroimaging datasets, that functional communication between brain regions destabilises with age, typically in the late 40’s.

That destabilisation correlates with poorer cognition and accelerates with insulin resistance, the researchers said.

Targeted experiments then showed this biomarker for brain ageing to be reliably modulated with consumption of different fuel sources.

As glucose decreases, and ketones increase, the stability of brain networks, the researchers said.

“The bad news is that we see the first signs of brain ageing much earlier than was previously thought,” said lead author Lilianne R. Mujica-Parodi, a professor at Stony Brook University.

“However, the good news is that we may be able to prevent or reverse these effects with diet, mitigating the impact of encroaching hypometabolism by exchanging glucose for ketones as fuel for neurons,” Mujica-Parodi said.

To conduct their experiments, brain network stability was established as a biomarker for ageing by using two large-scale brain neuroimaging (fMRI) datasets totaling nearly 1,000 individuals, aged 18 to 88.

Destabilisation of brain networks was associated with impaired cognition and was accelerated with Type 2 diabetes, an illness that blocks neurons’ ability to effectively metabolise glucose, according to the researchers.

To identify the mechanism as being specific to energy availability, they then held age constant and scanned an additional 42 adults under the age of 50 years with fMRI.

This allowed them to observe directly the impact of glucose and ketones on each individual’s brain.

📣 The Indian Express is now on Telegram. Click here to join our channel (@indianexpress) and stay updated with the latest headlines

For all the latest Lifestyle News, download Indian Express App.

7 thoughts on “Low carb diet may prevent, reverse age-related effects in brain: Study

  1. Good day very nice web site!! Guy .. Beautiful .. Superb ..
    I’ll bookmark your blog and take the feeds additionally?
    I am happy to search out numerous helpful info here in the publish, we
    want work out extra techniques in this regard, thanks for sharing.
    . . . . .

  2. Hello there, just became aware of your blog through Google, and found that it’s
    truly informative. I am gonna watch out for brussels.
    I will appreciate if you continue this in future.

    Numerous people will be benefited from your writing.


  3. I’m not sure exactly why but this website is loading extremely slow
    for me. Is anyone else having this issue or is it a problem on my end?
    I’ll check back later on and see if the problem still exists.

  4. What i do not understood is actually how you are
    now not actually much more smartly-favored
    than you might be right now. You are so intelligent. You
    already know therefore considerably in relation to this matter, made me for my part
    consider it from a lot of varied angles. Its like women and men are not fascinated
    unless it’s one thing to do with Girl gaga! Your individual stuffs great.
    At all times maintain it up! yynxznuh cheap flights

  5. Excellent post. I was checking constantly this weblog
    and I’m inspired! Extremely useful info specifically the
    remaining part 🙂 I take care of such info a lot. I was seeking this particular information for a long time.
    Thank you and best of luck.

  6. You really make it appear really easy along with your presentation but I in finding this matter to be really something that I feel
    I’d never understand. It sort of feels too complicated and very vast for
    me. I am looking ahead on your subsequent put up, I will try to get the hang
    of it!

Leave a Reply

Your email address will not be published.